blogging about crisp bio-S&T, especially CRISPR.


[2018-05-01論文1件追記]ヒト脳オルガノイドを脳に定着させたキメラマウス作出"An in vivo model of functional and vascularized human brain organoids" Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH. Nat ... もっと読む

1.造血器腫瘍モデルの作出と療法評価[出典] "Multiplex CRISPR/Cas9-Based Genome Editing in Human Hematopoietic Stem Cells Models Clonal Hematopoiesis and Myeloid Neoplasia” Tothova Z, 〜 Ebert BL7. Cell Stem Cell. 2017 Oct 5;21(4):547-555.e8.造血器腫瘍の ... もっと読む

1.ヒト結腸オルガノイド遺伝子ノックアウトから、大腸癌の体細胞変異過程を再現 [出典1] “Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.” Drost J et al. Science 14 Sep 2017.[出典2] 変異シグナチャー ... もっと読む