blogging about crisp bio-S&T, especially CRISPR.


[出典] "CRISPR/Cas9-based directed evolution in mammalian cells" Griesbeck O (MPI Neurobiologie) Curr Opin Struct Biol. 2021-03-27. タンパク質の指向性進化はこれまでin vitro技術や微生物発現システムに依存してきたが ... もっと読む

[crisp_bio感想: 久しぶりの'非-CRISPR & 非-新型コロナウイルス'論文][出典] "Improved protein structure refinement guided by deep learning based accuracy estimation" Hiranuma N, Park H, Baek M, Anishchenko I, Dauparas J, Baker D. (bioRxiv 2020-11-04) Nat Com ... もっと読む

2021-03-10 ブログ記事タイトルのタイポを訂正: David BarkerをDavid Bakerに訂正, 大変失礼いたしました。2021-03-09 初稿 -----------------------David Baker*コレクション [*] TED video "5 challenges we could solve by designing new proteins" 2021-03-09 タンパク質 ... もっと読む

[出典] "Improving Antibody Production In Stably Transfected CHO Cells by CRISPR‐Cas9‐mediated Inactivation of Genes Identified in a Large Scale Screen with Chinese" Lin PC [..] Song Z. Biotechnol J. 2020-10-20.  Bioprocessing Technology Institute (Sin ... もっと読む

出典[論文] "Designed protein logic to target cells with precise combinations of surface antigens" Lajoie MJ, Boyken SE, Salter AI [..] Baker D. Science. 2020-09-25. [Research Highlight] When de novo-designed protein logics meet CAR-T therapies. Xe M, Lu ... もっと読む