[出典] "Robust genome editing in adult vascular endothelium by nanoparticle delivery of CRISPR-Cas9 plasmid DNA" Zhang X [..] Zhao Y-Y. Cell Rep. 2022-01-04. https://doi.org/10.1016/j.celrep.2021.110196; Graphical abstract https://ars.els-cdn.com/content/ ...
もっと読む
タグ：デリバリー
CRSPR/Cas9の標的細胞へ効率的かつ一時的デリバリーに向けたアルファレトロウイルス由来Gag.MS2粒子の改良
[出典] "Improved alpharetrovirus-based Gag.MS2 particles for efficient and transient delivery of CRISPR/Cas9 into target cells" Baron Y [..] Schambach A, Galla M. Mol Ther Nucleic Acids. 2021-12-29. https://doi.org/10.1016/j.omtn.2021.12.033 Hannover Med ...
もっと読む
RPS5Aプロモーター駆動型Cas9によるコヨーテタバコのウイルス誘導型ゲノム編集の実現
[出典] "RPS5A Promoter-Driven Cas9 Produces Heritable Virus-Induced Genome Editing in Nicotiana attenuata " Oh Y, Kim S-G. Mol Cells. 2021-12-31. https://doi.org/10.14348/molcells.2021.0237 KAISTの研究グループは今回，SpCas9を発現させた野生型N. attenuata ...
もっと読む
CRISPR/Cas9プラスミドでリプログラムしたヒト臍帯間葉系幹細胞由来エクソソームを介した脊髄損傷の免疫療法
[出典] "Spinal cord injury target-immunotherapy with TNF-α autoregulated and feedback-controlled human umbilical cord mesenchymal stem cell derived exosomes remodelled by CRISPR/Cas9 plasmid" Wang B, Chang M, Zhang R, Wo J [..] Tang S, Yang S, Sun G. M ...
もっと読む
[N&V] アデノ随伴ウイルス (AAV)を介したCRISPR療法に対する免疫応答
[出典] NEWS & VIEWS "Immune Responses to Adeno-Associated Virus-Mediated CRISPR Therapy" Keeper AM (U Massachusetts Chan Medical School). Hum Gene Ther. 2021-12-16. https://doi.org/10.1089/hum.2021.29193.amk DMDイヌモデルでの実験で，AAV-CRISPR投与が，Cas ...
もっと読む
