[出典] REVIEW "CRISPR-Cas13 System as a Promising and Versatile Tool for Cancer Diagnosis, Therapy, and Research" Palaz F [..] Özcan A, Ozsoz M. ACS Synth Biol. 2021-05-26. https://doi.org/10.1021/acssynbio.1c00107 トルコのHacettepe U, Koc U, Afyonkara ...
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タグ：リキッドバイオプシー
新型コロナウイルス患者の血漿プロテオミクスから分かったこと
マサチューセッツ総合病院 (MGH)を主とする研究グループの報告[出典] "Longitudinal proteomic analysis of plasma from patients with severe COVID-19 reveal patient survival-associated signatures, tissue-specific cell death, and cell-cell interactions" Filbin MR ...
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CRISPR/Cas12aコラテラル活性をベースとする血中循環腫瘍DNAの超高感度バイオセンサー - 乳癌PIK3CA遺伝子変異
[出典] "Ultrasensitive detection of gene-PIK3CA<H1047R> mutation based on cascaded strand displacement amplification and trans-cleavage ability of CRISPR/Cas12a" Deng Y, Cao G, Chen X, Yang M, Huo D, Hou C. Talanta. 2021-04-20. https://doi.org/10.1016/j.t ...
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ctDNAに基づく診断実現に向けて, 標的DNA増幅が不要なCas12aバイオセンサーを開発
[出典] "CRISPR-Cas12a-Based Nucleic Acid Amplification-Free DNA Biosensor via Au Nanoparticle-Assisted Metal-Enhanced Fluorescence and Colorimetric Analysis" Choi JH, Lim J, Shin M, Paek SH, Choi JW. Nano Lett. 2020-12-21. https://doi.org/10.1021/acs.nano ...
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Cas9/sgRNAによる野生型DNA分解を介して血中循環腫瘍DNAの検出感度を1000倍向上
[出典] "Improved EGFR mutation detection sensitivity after enrichment by Cas9/sgRNA digestion and PCR amplification" Wang L [..] Hu Z, Luo D. Acta Biochim Biophys Sin (Shanghai) 2020-11-20. https://academic.oup.com/abbs/advance-article-abstract/doi/10.109 ...
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