[出典] "A CRISPR/Cas9 method facilitates efficient oligo-mediated gene editing in Debaryomyces hansenii " Strucko T [..] Martínez JL, Mortensen UH. Synthetic Biology 2021-10-12. https://doi.org/10.1093/synbio/ysab031 Technical University of Denmarkの研 ...
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タグ：代謝工学
CRISPR KOとCRISPRaによる酵母工場の向上 - 耐熱性好熱性酵母Ogataea thermomethanolica TBRC 656の場合
[出典] "Modulation of heterologous protein secretion in the thermotolerant methylotrophic yeast Ogataea thermomethanolica TBRC 656 by CRISPR-Cas9 system" Kruasuwan W [..] Roongsawang N. PLoS One. 2021-09-28. https://doi.org/10.1371/journal.pone.0258005 N ...
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CRAGE-CRISPRはバクテリアの二次代謝産物生合成遺伝子群の迅速な活性化を促進する
[注] CRAGE (chassis-independent recombinase-assisted genome engineering)[出典] "CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria" Ke J [..] Cheng JF, Yoshikuni Y. Cell Chem Biol. 2021-09-10. https:/ ...
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CRISPRiとオミックス解析により，遊離脂肪酸の高効率生産を実現する大腸菌標的遺伝子群を同定
[出典] "Genome-scale target identification in Escherichia coli for high-titer production of free fatty acids" Fang L [..] Song H. Nat Commun. 2021-08-17. https://doi.org/10.1038/s41467-021-25243-w 天津大学の研究グループからの論文．優れた微生物細胞工場の ...
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[レビュー] CRISPR-Casシステムによる微生物工場の進歩
[出典] REVIEW "Microbial production of chemicals driven by CRISPR-Cas systems" Shi S, Qi N, Nielsen J. Curr Opin Biotechnol. 2021-07-21. https://doi.org/10.1016/j.copbio.2021.07.002 北京化工大学とChalmers University of Technology (スエーデン)およびBioInn ...
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