乳酸脱水素酵素A (LDHA)を標的とするCRISPR/Cas9を脂質ナノ粒子で送達[出典] "Lipid nanoparticle-mediated CRISPR/Cas9 gene editing and metabolic engineering for anticancer immunotherapy" Ju H, Kim D, Oh YK. Asian J Pharm Sci 2022-08-22. https://doi.org/10.1016 ...
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タグ:代謝工学
CRISPR/Cas9を介した多重遺伝子編集によりシロイヌナズナでのヒドロキシ脂肪酸 (HSA)産生を促進
[出典] "Enhanced production of hydroxy fatty acids in Arabidopsis seed through modification of multiple gene expression" Park ME, Lee KR, Chen GQ, Kim HU. Biotechnol Biofuels Bioprod. 2022-06-18. https://doi.org/10.1186/s13068-022-02167-1 [著者所属] Sejo ...
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代謝スケールのCRISPRaスクリーンにより,鉄欠乏状態への耐性をもたらす因子を同定
[注] 代謝スケール:2,989種類の代謝酵素と低分子輸送体を標的とする32,509 sgRNAsを使用[出典] "Metabolic-scale gene activation screens identify SLCO2B1 as a heme transporter that enhances cellular iron availability" Unlu G [..] Birsoy K. Mol Cell 2022-06-16. ...
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好熱性菌類Myceliophthora thermophilaに適したBEを構築し,セルラーゼ転写因子の精密編集を実現
[出典] "Development of an Efficient C-to-T Base-Editing System and Its Application to Cellulase Transcription Factor Precise Engineering in Thermophilic Fungus Myceliophthora thermophila " Zhang C, Li N, Rao L, Li J, Liu Q, Tian C. Microbiol Spectr 2022- ...
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CRISPRaを利用してタバコの葉における代謝物組成を設計する
[出典] "Custom-made design of metabolite composition in N. benthamiana leaves using CRISPR activators" Selma S [..] Orzaez D. Plant Biotechnol J. 2022-05-05. https://doi.org/10.1111/pbi.13834 [著者所属] Instituto Biologia Molecular de Plantas, Universidad ...
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