blogging about crisp bio-S&T, especially CRISPR.


[出典] "CRISPR/Cas9-engineered universal CD19/CD22 dual-targeted CAR-T cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia" Hu Y et al. Clin Cancer Res 2021-02-24.[注] B-ALL (B細胞急性リン ... もっと読む

[出典] "An optimized workflow for CRISPR-Cas9 deletion of surface and intracellular factors in primary human T lymphocytes" Leoni C, Bianchi N, Vincenzetti L, Monticelli S. PLoS One. 2021-02-18. Università ... もっと読む

[出典] "Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators" Hou J, Wang Y, Shi L [..] Chen Y, Hwu P, Peng W. J. Immunother Cancer 2021 Feb. ... もっと読む

[出典] "Lymphohematopoietic Engineering Using Cas9 Base Editors" US20210040507 A1.発明者 Moriarity B, Webber B, Lonetree C-l, Diers M, Kluesner M, Lahr W, Pomeroy EJ.公開日 2021-02-11権利者 Regents of t ... もっと読む

[出典] REVIEW "Cas9-directed immune tolerance in humans—a model to evaluate regulatory T cells in gene therapy?" Wagner DL, Peter L, Schmueck-Henneresse M. Gene Ther 2021-02-11. Charité-Universitätsmedizin Be ... もっと読む