crisp_bio

blogging about crisp bio-S&T, especially CRISPR.

タグ:免疫・療法

[出典] "CRISPR/Cas9-engineered universal CD19/CD22 dual-targeted CAR-T cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia" Hu Y et al. Clin Cancer Res 2021-02-24. https://doi.org/10.1158/1078-0432.CCR-20-3863[注] B-ALL (B細胞急性リン ... もっと読む

[出典] "An optimized workflow for CRISPR-Cas9 deletion of surface and intracellular factors in primary human T lymphocytes" Leoni C, Bianchi N, Vincenzetti L, Monticelli S. PLoS One. 2021-02-18.  https://doi.org/10.1371/journal.pone.0247232 Università ... もっと読む

[出典] "Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators" Hou J, Wang Y, Shi L [..] Chen Y, Hwu P, Peng W. J. Immunother Cancer 2021 Feb. http://dx.doi.org/10.1136/jit ... もっと読む

[出典] "Lymphohematopoietic Engineering Using Cas9 Base Editors" US20210040507 A1. https://www.freepatentsonline.com/y2021/0040507.html発明者 Moriarity B, Webber B, Lonetree C-l, Diers M, Kluesner M, Lahr W, Pomeroy EJ.公開日 2021-02-11権利者 Regents of t ... もっと読む

[出典] REVIEW "Cas9-directed immune tolerance in humans—a model to evaluate regulatory T cells in gene therapy?" Wagner DL, Peter L, Schmueck-Henneresse M. Gene Ther 2021-02-11. https://doi.org/10.1038/s41434-021-00232-2 Charité-Universitätsmedizin Be ... もっと読む

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