[出典] "Cas9-induced targeted integration of large DNA payloads in primary human T cells via homology-mediated end-joining DNA repair" Webber BR [..] Moriarity BS. Nat Biomed Eng. 2023-12-13. https://doi.org/10.1038/s41551-023-01157-4 [著者所属] U Minneso ...
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タグ:免疫・療法
多価アプタマーを含むスマートDNAナノアセンブリーにより, 癌免疫療法に有用なCRISPR/Cas9の送達を制御する
[出典] "A Smart DNA Nanoassembly Containing Multivalent Aptamers Enables Controlled Delivery of CRISPR/Cas9 for Cancer Immunotherapy" Lv Z [..] Liu P, Yao C, Yang D. Adv Funct Mater. 2023-08-22. https://doi.org/10.1002/adfm.202311069 [著者所属] U Alabama ...
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RAG2-SCID患者由来造血幹細胞の遺伝子修正が, V(D)J-リコンビナーゼを回復し, リンパ球欠損を回復させる
[出典] "Genetically Corrected RAG2-SCID Human Hematopoietic Stem Cells Restore V(D)J-Recombinase and Rescue Lymphoid Deficiency" Pavel-Dinu M [..] Porteus MH. (bioRxiv 2022-07-13) Blood Adv 2023-12-14. https://doi.org/10.1182/bloodadvances.2023011766 [著 ...
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[プロトコル] CRISPR/Cas9技術によるCAR-T細胞のゲノム編集
[出典] Protocol "Genome Editing in CAR-T Cells Using CRISPR/Cas9 Technology" Andreu-Saumell I, Rodriguez-Garcia A, Guedan S. In: Siciliano, V., Ceroni, F. (eds) Cancer Immunotherapy. MIMB 2023-12-10 https://doi.org/10.1007/978-1-0716-3593-3_12 [著者所属] ...
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[20231215更新] CAR-T細胞療法を、適切な抗原を欠いている急性骨髄性白血病 (AML) を含む広汎な血液腫瘍の治療にも適用可能にする
2023-12-15 Genes & Immunity 誌のハイライト記事へのリンクを以下に追加 "Serving up whatever you wish: CRISPR-base editing generates novel cancer-restricted antigens for immunotherapy" Burkhardt UE, Fritsch EF. Genes Immun 2023-11-11. https://doi.org/10.103 ...
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