blogging about crisp bio-S&T, especially CRISPR.


[出典] "A robust platform for expansion and genome editing of primary human natural killer cells" Huang R-S, Lai M-C, Shih H-A, Lin S. J Exp Med 2021-01-12. ゲノム編集は、複雑なシグナル伝達回路の解明に加えて免疫療法の ... もっと読む

[出典] "Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide" Jan M [..] Maus MV, Ebert BL. Sci Transl Med. 2021-01-06.  CAR-T細胞療法は B細胞急性リンパ芽球性白血病とびまん性大細 ... もっと読む

[出典] "Cas9-cleavage sequences in minimal plasmids enhance non-viral genome targeting of CARs in primary human T cells" Jing R, Jiao P [..] Zhou C, Sadelain M, Sun J. bioRxiv. 2020-01-02 [プレプリント]. 癌免疫療 ... もっと読む

[出典] "Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1" Cotton AD [..] Wells JA. J Am Chem Soc 2021-01-04. PROTAC (Proteolysis-targeting chimeras)は、E3リ ... もっと読む

2020-12-15 更新 PD-L1 KO T細胞移植による難治性非小細胞性肺癌療法第1相試験の第6項に, 関連論説へのリンクと書誌情報を追加2020-05-03 初稿-------------------1. CBEとABEによる塩基編集を初めてRhodobacter sphaeroides 2.4.1に適用北京大学の研究グループが, C-to-T変 ... もっと読む