[出典]Deep Mutational Scanning: Perspective "Deep mutational scanning: a new style of protein science" Fowler DM, Fields S. Nat Methods 2014 Aug;11(8):801-7.News & Views： "Mutagenesis-based protein structure determination" Chiasson M, Fowler DM. Nat Ge ...
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タグ：分子間相互作用
タンパク質変性領域の変異が遺伝子疾患をもたらす機構
出典Preview "Human Diseases from Gain-of-Function Mutations in Disordered Protein Regions" Li XH, Babu MM. Cell. 2018 Sep 20. Article "Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs" Meyer K, Kirchner M, Uyar B [..] Diecke ...
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新たな近接依存性標識法"PUP-IT"によるPPI解析
出典"A proximity-tagging system to identify membrane protein–protein interactions" Liu Q, Zheng J [..] Wang H, Zhuang M. Nat Methods. 2018 Aug 13；"A Novel Proximity Tagging System Tracks Protein-Protein Interactions" ShanghaiTech University News 2018-0 ...
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酵母とヒト細胞内の分子クラウディングを新たなプローブで探る
出典[Research Highlight]"Probes for molecular crowding" Strack R. Nat Methods. 2018 Jul 31．[論文]"mTORC1 controls phase separation and the biophysical properties of the cytoplasm by tuning crowding" Delarue M, Brittingham GP, Pfeffer S [..] Engel BD, H ...
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スーパーオキシドディスムターゼ(SOD)と小胞体膜タンパク質 Derlin-1の相互作用は家族性ALS治療の標的である
[出典]"A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model" Tsuburaya N [..] Ichijo H.Nat Commun 2018 Jul 10.Cu, Zn superoxide dismutase(スーパーオキシドディスムターゼ) (SOD1)遺伝子の変異によるALSの発症機序 ...
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