crisp_bio

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タグ:合成致死

[出典] "Combined genome-scale fitness and paralog synthetic lethality screens with just 44k clones: the IN4MER CRISPR/Cas12a multiplex knockout platform" Anvar NE [..] Hart T. bioRxiv 2023-01-03 [プレプリント]. https://doi.org/10.1101/2023.01.03.522655 [ ... もっと読む

[出典] "Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome" Parrish PCR, Thomas JD [..] Berger AH. Cell Rep 2021-08-31. https://doi.org/10.1016/j.celrep.2021.109597 [著者所属]  Fred Hutchinson Cancer Research Center, U W ... もっと読む

[出典] "Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines" De Kegel B, Ryan CJ. Cell Systems 2021-09-15. https://doi.org/10.1016/j.cels.2021.08.006 [著者所属] U College Dublin, Wellcome Sanger Institute;右 ... もっと読む

[出典] "Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors" Feng X, Tang M, Dede M [..] Hart T, Chen J. Sci Adv 2022-05-13. https://doi.org/10.1126/sciadv.abm6638 [著者所属] UTEX MD Anderson Cance ... もっと読む

[出典] "CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition" Gallo D, Young JTF, Fourtounis J [..] Marshall CG, Durocher D. Nature 2022-04-28. https://doi.org/10.1038/s41586-022-04638-9 [著者所属] Mount Sinai Hospital, Repare Therapeut ... もっと読む

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