crisp_bio

blogging about crisp bio-S&T, especially CRISPR.

タグ:合成致死

2021-05-02 改題の上,査読付きCell  Death and Disease誌から出版2019-08-29 初稿-----------------------[出典] "Genome-wide CRISPR screens reveal synthetic lethal interaction between CREBBP and EP300 in diffuse large B-cell lymphoma" Nie M [..] Zhang F, Pan- ... もっと読む

[リンクのみ] "CRISPR-mediated kinome editing prioritizes a synergistic combination therapy for FGFR1-amplified lung cancer" Yang Z [..] Peng R-W. Cancer Res. 2921-03-08. https://doi.org/10.1158/0008-5472.CAN-20-2276 ... もっと読む

[出典] "Combinatorial CRISPR screen identifies fitness effects of gene paralogues" Thompson NA, Ranzani M, van Der Weyden L [..] Adams DJ. Nat Commun 2021-02-26.  https://doi.org/10.1038/s41467-021-21478-9 Wellcome Sanger Instituteを主とする研究グループ ... もっと読む

[出典] "CRISPR/Cas9 screening identifies a kinetochore-microtubule dependent mechanism for Aurora-A inhibitor resistance in breast cancer" Chen A, Wen S [..] Wang Z, Liu Q. Cancer Commun (London). 2021-01-20. https://doi.org/10.1002/cac2.12125オーロラキナ ... もっと読む

[出典] Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma. George SL et al. EBioMecicine 2020-08-23. https://doi.org/10.1016/j.ebiom.2020.102971 転帰不良 (poor outcome)な神経芽腫は、主として、MYCN増幅, ... もっと読む

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