2023-09-07 bioRxiv投稿v.2に準拠してタイトルなど一部改訂:2023-01-07 bioRxiv投稿v.1に準拠した初稿[出典] "Efficient gene knockout and genetic interactions: the IN4MER CRISPR/Cas12a multiplex knockout platform Combined genome-scale fitness and paralog synt ...
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タグ:合成致死
pgMAP: CRISPR DKOスクリーンに由来するgRNAのリードのマッピングを可能にするパイプライン
[注] pgMAP (paired guide RNA mapper); DKO (double knock out)[出典] "pgMAP: a pipeline to enable guide RNA read mapping from dual-targeting CRISPR screens" Parrish PCR [..] Berger AH. arXiv 2023-06-01 (preprint). https://doi.org/10.48550/arXiv.2306.00944 [ ...
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ゲノムワイドCRISPR/Cas9スクリーンにより悪性軟部腫瘍のATR阻害剤耐性のドライバーを同定
[注] 悪性南部腫瘍 (soft-tissue sarcomas: STS)[出典] "Genome-wide CRISPR/Cas9 library screening identified ATM signaling network genes as critical drivers for resistance to ATR inhibition in soft-tissue sarcomas: synthetic lethality and therapeutic implica ...
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ゲノムワイドCRISPRスクリーンにより、大腸癌と膵癌にSMAD4との合成致死をもたらすRAB10を同定
[出典] "Genome-wide CRISPR screen reveals RAB10 as a synthetic lethal gene in colorectal and pancreatic cancers carrying SMAD4 loss" Erasmus H [..] Marcireau C. Cancer Research Communications. https://doi.org/10.1158/2767-9764.CRC-22-0301 [著者所属] Sano ...
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CRISPR-Cas9ダブルKOスクリーンによって、合成致死と腫瘍抑制の関係にある遺伝子パラログペアを発見
[出典] "Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome" Parrish PCR, Thomas JD [..] Berger AH. Cell Rep 2021-08-31. https://doi.org/10.1016/j.celrep.2021.109597 [著者所属] Fred Hutchinson Cancer Research Center, U W ...
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