crisp_bio

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タグ:合成致死

2023-09-07 bioRxiv投稿v.2に準拠してタイトルなど一部改訂:2023-01-07 bioRxiv投稿v.1に準拠した初稿[出典] "Efficient gene knockout and genetic interactions: the IN4MER CRISPR/Cas12a multiplex knockout platform Combined genome-scale fitness and paralog synt ... もっと読む
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[注] pgMAP (paired guide RNA mapper); DKO (double knock out)[出典] "pgMAP: a pipeline to enable guide RNA read mapping from dual-targeting CRISPR screens" Parrish PCR [..] Berger AH. arXiv 2023-06-01 (preprint). https://doi.org/10.48550/arXiv.2306.00944 [ ... もっと読む
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[注] 悪性南部腫瘍 (soft-tissue sarcomas: STS)[出典] "Genome-wide CRISPR/Cas9 library screening identified ATM signaling network genes as critical drivers for resistance to ATR inhibition in soft-tissue sarcomas: synthetic lethality and therapeutic implica ... もっと読む
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[出典] "Genome-wide CRISPR screen reveals RAB10 as a synthetic lethal gene in colorectal and pancreatic cancers carrying SMAD4 loss" Erasmus H [..] Marcireau C. Cancer Research Communications. https://doi.org/10.1158/2767-9764.CRC-22-0301 [著者所属] Sano ... もっと読む
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[出典] "Discovery of synthetic lethal and tumor suppressor paralog pairs in the human genome" Parrish PCR, Thomas JD [..] Berger AH. Cell Rep 2021-08-31. https://doi.org/10.1016/j.celrep.2021.109597 [著者所属]  Fred Hutchinson Cancer Research Center, U W ... もっと読む
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