[出典] "Small-molecule inhibitors of histone deacetylase improve CRISPR-based adenine base editing" Shin HR [..] Kim Y. Nucleic Acids Res. 2021-02-05. https://doi.org/10.1093/nar/gkab052 University of Ulsan College of MedicineとSeoul National University ...
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タグ：塩基エディター
CBEをベースとして代謝リプログラミングに必要な多重遺伝子の同時発現調節を実現
[出典] "In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing" Wang Y, Cheng H, Liu Y [..] Zheng P, Wang M, Sun J, Ma Y. Nat Commun. 2021-01-29. https://doi.org/10.1038/s41467-021-21003-y T ...
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Target-AIDによりアグロバクテリウムを介した植物形質転換の効率向上
[出典] "Efficient CRISPR-mediated base editing in Agrobacterium spp." Rodrigues SD [..] Van Montagu M [..] De Coninck B, Pauwels L. PNAS 2021-01-12. https://doi.org/10.1073/pnas.2013338118 KU LeuvenとGhent Universityを主とする研究グループは今回、アグロバ ...
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[プロトコル] CBEとABEによる哺乳類培養細胞の精密ゲノム編集
[出典] "Precision genome editing using cytosine and adenine base editors in mammalian cells" Huang TP, Newby GA, Liu DR. Nat Protoc 2021-01-18. https://doi.org/10.1038/s41596-020-00450-9 塩基エディターのCBE (C•G-to-T•A変換)とABE (A•T-to-G•C)の編集効 ...
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CBEとABEによるモデル植物ヒメツリガネゴケ遺伝子機能解析
[出典] METHOD "A blue‐print for gene function analysis through Base Editing in the model plant Physcomitrium (Physcomitrella) patens" Guyon‐Debast A et al. New Phytologist. 2021-01-09. https://doi.org/10.1111/nph.17171 Institut Jean‐Pierre Bourginを主 ...
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