blogging about crisp bio-S&T, especially CRISPR.


[2018-05-01論文1件追記]ヒト脳オルガノイドを脳に定着させたキメラマウス作出"An in vivo model of functional and vascularized human brain organoids" Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, Johnston S, Parylak SL, Jin X, Gage FH. Nat ... もっと読む

[出典] “Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1” Schiroli G, ~ Genovese P, Naldini L. SciTransl Med. 2017 Oct 11;9(411). pii: eaan0820. L. NaldiniとP. Genoves ... もっと読む

[出典] “FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling” Arias-Fuenzalida J, Jarazo J, Qing X, Walter J, Gomez-Giro G, Nickels SL, Zaehres H, Schöler HR, Schwamborn JC. Stem Cell Reports. 2017 Sep 26. pii: S2 ... もっと読む

1.ヒト結腸オルガノイド遺伝子ノックアウトから、大腸癌の体細胞変異過程を再現 [出典1] “Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer.” Drost J et al. Science 14 Sep 2017.[出典2] 変異シグナチャー ... もっと読む