crisp_bio

blogging about crisp bio-S&T, especially CRISPR.

タグ:神経変性

[出典] PERSPECTIVE "CRISPR-activated patient fibroblasts for modeling of familial Alzheimer's disease" Inoue K. Neurosci Res. 2021-04-02. https://doi.org/10.1016/j.neures.2021.03.008 神経変性疾患モデルシステムをCRISPR SAM転写活性化技術によって構築・実証 ... もっと読む

[出典] "Complete sequencing of expanded SAMD12 repeats by long-read sequencing and Cas9-mediated enrichment" Mizuguchi T [..] Matsumoto N. Brain. 2021-04-01. https://doi.org/10.1093/brain/awab021 BAFMEの病因としてSAMD12A 遺伝子における多型なTTTTA反復 ... もっと読む

[出典] "Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro" Guyon A, Rousseau J, Bégin F-G, Bertin T, Lamothe G, Tremblay JP. Mol Ther Nucleic Acids. 2021-03-01. https://doi.org/10.1016/j.o ... もっと読む

[出典] "Generation of APOE knock-down SK-N-SH human neuroblastoma cells using CRISPR/Cas9: A novel cellular model relevant to Alzheimer's disease research" Sonia Muñoz S, Garner B, Ooi L. Biosci Rep. 2021-02-12. https://portlandpress.com/bioscirep/articl ... もっと読む

[出典] "Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases" Ye T [..] Ip NY. Commun Biol 2021-02-12. https://doi.org/10.1038/s42003-021-01722-0 香港科技大学を主とする研究グループは今回、Cas9ニッカーゼ (Cas9n)ペアによるアレル ... もっと読む

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