crisp_bio

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タグ:神経変性

2024-02-22 フリードライヒ失調症iPSC由来神経細胞における小胞体-ミトコンドリア間の接触と小胞体ストレス応答 (UPR) をCRISPR-Cas9遺伝子編集で改善[出典] "Gene editing improves endoplasmic reticulum-mitochondrial contacts and unfolded protein response in Friedr ... もっと読む
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[出典] "Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons" Kumar SS [..] Shalem O. Sci Adv. 2024-02-09. https://doi.org/10.1126/sciadv.adj4767 [所属] U Pennsylvania, Children's Ho ... もっと読む
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[注] ICMA-1 (細胞間接着分子-1);外傷性脳損傷 (traumatic brain injury: TBI)[出典] "ICAM-1 deletion using CRISPR/Cas9 protects the brain from traumatic brain injury-induced inflammatory leukocyte adhesion and transmigration cascades by attenuating the paxil ... もっと読む
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[出典] "CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly" Sweeney KM [..] Shalem O. PLoS Genetics 2024-02-05. https://doi.org/10.1371/journal.pgen.1011138 [所 ... もっと読む
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[注] 神経発達障害 (neurodevelopmental disorders: NDDs)[出典] REVIEW "Strategies for dissecting the complexity of neurodevelopmental disorders" Sun J, Noss S, Banerjee D, Das M, Girirajan S. Trends Genet. 2023-11-08. https://doi.org/10.1016/j.tig.2023.10.0 ... もっと読む
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