[出典] "Exploiting a conjugative endogenous CRISPR-Cas3 system to tackle multidrug-resistant Klebsiella pneumoniae" Zhou Y, Yang Y, Li X [..] Yu F, Chen L, Jiang X. eBioMedicine 2023-01-23. https://doi.org/10.1016/j.ebiom.2023.104445 [著者所属] Tongji Sch ...
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タグ：薬剤耐性
小型のCRISPRiによるカルバペネム耐性肺炎桿菌の天然プラスミド由来遺伝子発現の効率的抑制
[出典] "Efficient Suppression of Natural Plasmid-Borne Gene Expression in Carbapenem-Resistant Klebsiella pneumoniae Using a Compact CRISPR Interference System" Yao S [..] Feng J, Zhang G. Antimicrob Agents Chemother 2022-10-12. https://doi.org/10.1128/a ...
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ゲノムスケールCRISPRスクリーンを介して、肝細胞がんのレンバチニブ耐性を駆動する因子としてLAPTM5を同定
[注] LAMPTM5 (lysosomal protein transmembrane 5)[出典] "Genome-Scale CRISPR Screen Identifies LAPTM5 driving lenvatinib resistance in hepatocellular carcinoma" Pan J [..] Gao Q. Autophagy 2022-08-29. https://doi.org/10.1080/15548627.2022.2117893 [著者所属 ...
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抗-CRISPR (Acr)を組み込んだバクテリオファージを介して薬剤耐性緑膿菌の感染を抑制
[出典] "Engineered Bacteriophages Containing Anti-CRISPR Suppress Infection of Antibiotic-Resistant P. aeruginosa " Qin S, Liu Y, Chen Y et al. Microbiol Spectr 2022-08-16. https://doi.org/10.1128/spectrum.01602-22 [著者所属] Sichuan University, Univer ...
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バクテリアの内在転写産物を標的とするCRISPR-Cas13aを接合性プラスミドで送達することで、病原体特異的抗菌を実現
[注] CKP: Cas13a-based killing plasmid[出典] "Pathogen-Specific Bactericidal Method Mediated by Conjugative Delivery of CRISPR-Cas13a Targeting Bacterial Endogenous Transcripts" Song Z [..] Tang Y. Microbiol Spectr 2022-08-11. https://doi.org/10.1128/spec ...
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