[出典] "Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers" Ding Y [..] Wood KC, Wang XF. Nat Commun. 2018 Oct 15. 乳癌に対するHER2標的療法はHER2陽性乳癌患者の全生存期間を顕著に伸ばすが、ハイリスク ...
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タグ:薬剤耐性
CRISPR KOスクリーンによる膵癌の併用療法開発と薬剤感受性予測
[出典] "CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response" Szlachta K, Kuscu C, Tufan T [..] Adli M. Nat Commun. 2018 Oct 15.膵癌 (pancreatic ductal adenocarcinoma, PDAC)の患者の93%にKR ...
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CRISPR_2018/10/08-2 (9件)
1. 塩基編集 (BE3改良版)により始原生殖細胞発生の鍵を握るアミノ酸を同定[出典] "CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development" Li Q [..] Chen Y, Li J. Nat Cell Biol. 201 ...
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CRISPRメモ_2018/09/30 (10件)
1. ADAM17とPD1のCRISPR/Cas9ノックアウトによりNK細胞免疫療法の可能性を広げた[出典] "A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy" Pomeroy EJ [..] Moriarity BS. bioRxiv. 2018.Sep 29.NK (ナチュラルキラー)細胞は ...
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ブドウ球菌の病原性アイランドを抗菌性アイランドへ改変する
[出典] "Conversion of staphylococcal pathogenicity islands to CRISPR-carrying antibacterial agents that cure infections in mice" Ram G, Ross HF, Novick RP, Rodriguez-Pagan I, Jiang D. Nat Biotechnol. 2018 Sep 24.背景黄色ブドウ球菌 (Staphylococcus aureus) ...
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