blogging about crisp bio-S&T, especially CRISPR.


[出典] Genome-wide CRISPR/Cas9 library screening identified PHGDH as a critical driver for Sorafenib resistance in HCC. Wei L [..] Wong CCL, Wong CM. Nat Commun. 2019-10-15.ソラフェニブはHCCの標準治療薬であるが耐性の発生を伴う。香港大学の研究グループは、 ... もっと読む

[出典] NEWS: Treatment for extreme drug-resistant tuberculosis wins US government approval. Maxmen A. Nature 2019-08-14; FDA Approves New Treatment for Highly Drug-Resistant Forms of Tuberculosis. TB Alliance. 2019-08-14.WHOによると、世界中で毎年およそ50 ... もっと読む

[出典]  "FLASH - a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences" Quan J, Langelier C, Kuchta A [..] Crawford ED. Nucleic Acids Res 2019-05-22;特許公開 US20190300935A1 Method for finding low abundance ... もっと読む

多剤耐性菌ファージ療法の症例多剤耐性アシネトバクター [出典] "Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection" Schooley RT, Biswas B et al. A ... もっと読む

[出典] "A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action" Yang JH, Wright SN, Hamblin M [..] Collins JJ. Cell 2019-05-09.背景機械学習によって、生体信号 (biological signals)と実験測定したフェノタイプの相関関係を明らかにす ... もっと読む