blogging about crisp bio-S&T, especially CRISPR.


ASH Annual Meeting Abstracts (Blood. 2018 132 Spplement 1)から CRISPR/Cas9システムの新たな送達手段:CAR-細胞外小胞 (EV)の腫瘍細胞トロピズムを利用:Targeting Burkitt Lymphoma By CAR-Extracellular Vesicles: A Tropism-Delivery Platform for CRISPR/Cas9 Sys ... もっと読む

[出典] "Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers" Ding Y [..] Wood KC, Wang XF. Nat Commun. 2018 Oct 15. 乳癌に対するHER2標的療法はHER2陽性乳癌患者の全生存期間を顕著に伸ばすが、ハイリスク ... もっと読む

[出典] "CRISPR knockout screening identifies combinatorial drug targets in pancreatic cancer and models cellular drug response" Szlachta K, Kuscu C, Tufan T [..] Adli M. Nat Commun. 2018 Oct 15.膵癌 (pancreatic ductal adenocarcinoma, PDAC)の患者の93%にKR ... もっと読む

1. 塩基編集 (BE3改良版)により始原生殖細胞発生の鍵を握るアミノ酸を同定[出典] "CRISPR-Cas9-mediated base-editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development" Li Q [..] Chen Y, Li J. Nat Cell Biol. 201 ... もっと読む

1. ADAM17とPD1のCRISPR/Cas9ノックアウトによりNK細胞免疫療法の可能性を広げた[出典] "A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy" Pomeroy EJ [..] Moriarity BS. bioRxiv. 2018.Sep 29.NK (ナチュラルキラー)細胞は ... もっと読む