blogging about crisp bio-S&T, especially CRISPR.


出典"Design of an allosterically modulated doxycycline and doxorubicin drug-binding protein" Schmidt K, Gardill BR, Kern A, Kirchweger P, Börsch M, Muller YA. Proc Natl Acad Sci U S A. 2018 May 14.成果Yves A. Muller (Friedrich-Alexander-Universität Erla ... もっと読む

出典[論文] "The dTAG system for immediate and target-specific protein degradation" Nabet B[..]Gray NS, Bradner JE. Nat Chem Biol. 2018 May;14(5):431-441. Published online 2018 Mar 26.[News & Views] "TAGing for destruction" Yesbolatova A, Kanemaki MT. Nat ... もっと読む

出典"Evolution of a designed protein assembly encapsulating its own RNA genome" Butterfield GL, ~ Baker D. Nature. 2017 Dec 13.ウイルスを利用したドラッグデリバリートマトブッシースタントウイルスのコートタンパク質二十面体構造が2.9 Åの高分解能で解かれて以来 ... もっと読む

[2019-09-27 crisp_bio追記] Nature Protocols投稿:"Acute and rapid degradation of endogenous proteins by Trim-Away" Clift D, So C, McEwan WA, James LC, Schuh M. Nat Protoc. 2018 Sep 24.[出典] "A Method for the Acute and Rapid Degradation of Endogenous Prot ... もっと読む

出典[展望] Whitehead TA. “A peptide mimic of an antibody” Science. 2017 Oct 27;358(6362):450-451.[論文] Kadam RU, ~ van Dongen MJP, Wilson IA. “Potent peptidic fusion inhibitors of influenza virus” Science. 2017 Oct 27;358(6362):496-502. Published onl ... もっと読む