blogging about crisp bio-S&T, especially CRISPR.


2021-02-28 The CRISPR Journal誌からの刊行論文の書誌情報とリンクを追加 (挿入図はbioRxiv版から引用)2020-09-08 初稿-----------------------[出典] Self-cutting and integrating CRISPR plasmids (SCIPs) enable targeted genomic integration of genetic payloads for ... もっと読む

[出典] "CRISPR/Cas9-engineered universal CD19/CD22 dual-targeted CAR-T cell therapy for relapsed/refractory B-cell acute lymphoblastic leukemia" Hu Y et al. Clin Cancer Res 2021-02-24.[注] B-ALL (B細胞急性リン ... もっと読む

[出典] "Lymphohematopoietic Engineering Using Cas9 Base Editors" US20210040507 A1.発明者 Moriarity B, Webber B, Lonetree C-l, Diers M, Kluesner M, Lahr W, Pomeroy EJ.公開日 2021-02-11権利者 Regents of t ... もっと読む

[出典] REVIEW "Applications of CRISPR Genome Editing to Advance the Next Generation of Adoptive Cell Therapies for Cancer" Fix SM, Jazaeri AA, Hwu P. Cancer Discov. 2021-02-09. The University of Texas MD Ander ... もっと読む

[出典] "Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide" Jan M [..] Maus MV, Ebert BL. Sci Transl Med. 2021-01-06.  CAR-T細胞療法は B細胞急性リンパ芽球性白血病とびまん性大細 ... もっと読む