[出典] REVIEW "CRISPR-Cas tools to study gene function in cytokinesis" Husser MC, Skaik N, Martin VJJ, Piekny A (Concordia U, Montréal). J Cell Sci. 2021-04-22. https://journals.biologists.com/jcs/article/134/8/jcs254409/258468/CRISPR-Cas-tools-to-study ...
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タグ：CRISPRa
新型コロナウイルス感染を左右する宿主因子を，ゲノムワイドCRISPR機能喪失/機能獲得スクリーンにより同定
[出典] "Genome-wide, bidirectional CRISPR screens identify mucins as critical host factors modulating SARS-CoV-2 infection" Biering SB, Sarnik SA [..] Harris E, Konermann S, Hsu PD. bioRxv. 2021-04-23 [プレプリント]. https://doi.org/10.1101/2021.04.22.44 ...
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CRISPRaスクリーンを介して，マウスにて転移性肺腫瘍の定着を亢進する新たな膜タンパク質を同定
[出典] "CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation" van der Weyden, Harle V, Turner G [..] Adams DJ. Commun Biol. 2021-03-23. https://doi.org/10.1038/s42003-021-01912-w Wellcome Sange ...
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MiniCAFE: 生体内での強力なCRISPRaを実現するdCjCas9
[出典] "MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo" Zhang X, Lv S, Luo Z [..] Zhou Q, Zhang Z-N, Rong Z. Nucleic Acids Res. 2021-03-22. https://doi.org/10.1093/nar/gkab174 SpCas9のヌクレア ...
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CRISPRa/iは神経系CaV3.2チャネロパチー研究に有用である
[出典] "A versatile CRISPR toolbox to study neurological CaV3.2 channelopathies by promoter-mediated transcription control" Tsortouktzidis D [..] van Loo KMJ. bioRxiv. 2021-03-20 [プレプリント]. https://doi.org/10.1101/2021.03.20.436250 University of Bo ...
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