[出典] "Targeted CRISPR activation and knockout screenings identify novel drug transporters" Li U, Tan M, Sun S, Sea E, Pang B. Research Square 2023-07-03 (preprint). https://doi.org/10.21203/rs.3.rs-3119383/v1 [著者所属] Leiden U Medical Center 抗癌剤 ...
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タグ:CRISPRa
細胞に目的とする機能をもたせる新たな合成RNA回路構築法を開発
[出典] "Establishing artificial gene connections through RNA displacement–assembly-controlled CRISPR/Cas9 function" Wang WJ, Lin J [..] Xing X, Xu L. Nucleic Acids Res 2023-07-03. https://doi.org/10.1093/nar/gkad558 [著者所属] Sun Yat-Sen U, Jinan Univ ...
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集束超音波 (focused ultrasound: FUS) によるCRISPRa/CRISPRiの時空間制御を実現
[出典] "Spatiotemporal Control of Genomics and Epigenomics by Ultrasound" Wu Y, Huang Z, Liu Y [..] Wang Y. bioRxiv 2023-06-23 [preprint] https://doi.org/10.1101/2023.06.21.544125 [著者所属] UCSD, UCSF, Peking University Health Science, Shenzhen Bay Lab ...
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ガイドRNAを環状にするとCas12a/Cas13dをベースとするDNA/RNAの編集効率が向上する
[出典] "Engineered circular guide RNAs boost CRISPR/Cas12a-and CRISPR/Cas13d-based DNA and RNA editing" Zhang X , Wang X [..] Lin Y, Zhao X, Rong Z. Genome Biol 2023-06-23. https://doi.org/10.1186/s13059-023-02992-z [著者所属] Southern Medical U. Cas12a ...
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移植に際してドナー肺の炎症性損傷の課題をCRISPRaを介したIL-10の転写活性化により解決
[出典] "Immunomodulation of the donor lung with CRISPR-mediated activation of IL-10 expression" Masaki K, Juvet S, Yeung J [..] Cypel M, Liu M, Keshavjee S. J Heart Lung Transplant 2023-06-12. https://doi.org/10.1016/j.healun.2023.06.001 [著者所属] Toront ...
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