[出典] "Specific multivalent molecules boost CRISPR-mediated transcriptional activation" Chen R [..] Cui H, Chen W. Nat Commun. 2024-08-22. https://doi.org/10.1038/s41467-024-51694-y [所属] Southern U Science and Technology, The First Affiliated Hospital …
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タグ:CRISPRa
[レビュー] 眼疾患を対象とするCRISPRaによる遺伝子治療と治療応用の可能性
[出典] REVIEW "Genetic therapies and potential therapeutic applications of CRISPR activators in the eye" BWJ Ng [..] Cehajic-Kapetanovic J. Prog Retin Eye Res 2024-08-08. https://doi.org/10.1016/j.preteyeres.2024.101289 [所属] Oxford Eye Hospital, Nuffie …
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CRISPRaスクリーンにより、FBXO22を介して機能するPROTAC候補を発見
[注] CRISPRa (CRISPR転写活性化);PROTAC (proteolysis-targeting chimera / 標的蛋白質分解誘導キメラ化合物)[出典] "A CRISPR activation screen identifies FBXO22 supporting Targeted Protein Degradation" Basu A [..] Zhang X. (bioRxiv 2023-09-16) Nat Chem Biol. …
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ゲノムワイドCRISPRaスクリーニングにより、フェロトーシスの抑制因子としてSWI/SNF ATPaseを同定
[出典] "CRISPR activation screens identify the SWI/SNF ATPases as suppressors of ferroptosis" Bhat KP [..] Ye X. Cell Rep 2024-06-11. https://doi.org/10.1016/j.celrep.2024.114345 [所属] Genentech, Roche Canada, 7N Sp. Z O. O. by order of Roche Polska;グ …
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CRISPRaを介したEBV再活性化とガンシクロビルの併用によるEBV陽性がん細胞の標的根絶療法
[出典] "Targeted eradication of EBV-positive cancer cells by CRISPR/dCas9-mediated EBV reactivation in combination with ganciclovir" Sugiokto FG, Li R. mBio. 2024-06-14. https://doi.org/10.1128/mbio.00795-24 [所属] U Pittsburgh, U Pittsburgh Medical Cent …
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