crisp_bio

blogging about crisp bio-S&T, especially CRISPR.

タグ:anti-CRISPR

[出典] "CRISPR Meets Its Match" Choi CQ. ACS Cent Sci. 2021-04-20. https://doi.org/10.1021/acscentsci.1c00427 CRISPR-Cas9システムを阻害するAcrsファミリーは50種類を超え,配列が極めて多様であり,またCas9を阻害する分子機序が多様なことが知られている.利用Cas ... もっと読む

[出典] "Saccharomyces cerevisiae Synthetic Transcriptional Networks Harnessing dCas12a and Type V-A anti-CRISPR Proteins" Yu L. Marchisio MA. ACS Synth Biol. 2021-04-05. https://doi.org/10.1021/acssynbio.1c00006 天津大学の研究チームは,S. cerevisiae に ... もっと読む

[出典] "Anti-CRISPR AcrIF9 functions by inducing the CRISPR–Cas complex to bind DNA non-specifically" Lu W-T, Trost CN, Müller-Esparza H, Randau L, Davidson AR. Nucleic Acids Res. 2021-02-28. https://doi.org/10.1093/nar/gkab092 University of TorontoとU ... もっと読む

[出典] REVIEW "Small Nucleic Acids and the Path to the Clinic for Anti-CRISPR" Barkau CL, O'Reilly D, Eddington SB, Damha MJ, Gagnon KT.  Biochem Pharmacol 2021-02-26. https://doi.org/10.1016/j.bcp.2021.114492 先行研究で核酸ベースのCas9阻害剤"anti-crRNA ... もっと読む

[出典] "Anti-CRISPR AcrIE2 binds the type I-E CRISPR-Cas complex but does not block DNA binding" Mejdani M, Pawluk A, Maxwell KL, Davidson AR. J Mol Biol 2020-12-16. https://doi.org/10.1016/j.jmb.2020.166759 抗CRISPRタンパク質群の配列、構造および作用機序 ... もっと読む

↑このページのトップヘ